If Kishimoto sticks true to the actual powers he gave her, and the actual powers he gave Sasuke, then between that and her marvelously cool head under fire compared to Sasuke's total bugfutsitude at this point, I think Sakura has more than a fighting chance. She'll reduce him to a fine layer of goo.

On the other hand, if Kishimoto arbitrarily decides he feels like having a damsel for Naruto and the boys to show up and save from her own Foolish Attempt To Fight A Man? Sakura could be the fecking Hokage and she'd still get her clock cleaned.

So...no bets. >.>

(In other news, it would be totally awesome if Sasuke went blind. Seriously, think of all the problems it would fix. Not to mention the karma of it...)