Uh, Wesley got killed after his girlfriend's soul was obliterated and her body overtaken by a demon who grew to have some affection for Wesley, but who had to watch him die in the end. FYI, soul-obliteration means that Wes is never seeing said girlfriend in any afterlife, because she's not only dead, she's been wiped from existence.

Also, Spike only had love/hate relationships, and pretty much all women treat him like shit except for Buffy's mom, who died.